American Indian and Alaska Native (AIAN) women have made important advances socially, economically, and politically—they are starting their own businesses, getting elected to congress, and serving essential roles in their families and communities. Despite their efforts, they continue to face a range of obstacles to their and their family’s economic wellbeing and overall economic security. The COVID-19 pandemic has thrown the overall inequalities facing AIAN women into sharp relief— particularly for AIAN women who live on reservations where economic opportunities may be especially limited, relying heavily on casinos and public sector employment. Poor quality and overcrowded housing, a lack of access to quality health care, nutrition, and sometimes even basic access to running water make it more difficult to keep families safe.